Imaging Inflammation in Autoimmune Diabetes

Completed

Conditions studied: Diabetes Mellitus, Type 1

In brief

The purpose of this study is to determine whether magnetic resonance imaging (MRI) with ferumoxtran-10 can be used to detect changes in the pancreas associated with autoimmune diabetes.

Key facts

Study ID

NCT00585936

Run by

Joslin Diabetes Center

People needed

30

Starts

2007-09-01

Expected to finish

2010-03-01

Last updated by the study team

2011-11-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Recent onset type 1 diabetes as defined by clinical diagnosis within the last 6 months and age less than 30 or at least one islet autoantibody marker (GAD, IAA, or IA-2).
• or
• High risk of pre-type 1 diabetes as defined by first degree family relative with type 1 diabetes and at least one islet autoantibody marker (GAD, IAA, or IA-2).
• or
• Individuals with established type 1 diabetes of greater than 6 months duration who were under age 30 or at least one islet autoantibody marker positive (GAD, IAA, or IA-2) at time of diagnosis or who currently are GAD or IA-2 autoantibody marker positive.
• or
• Normal control as defined by no family history of type 1 diabetes and normal tolerance test (tolerance testing to be performed as part of protocol).

You may not qualify if…

• Individuals under 18 years of age
• Individuals unable or unwilling to give informed consent/HIPAA authorization
• Individuals who are clinically unstable
• Individuals with any contraindications to MRI examination, for example, individuals with pacemakers
• Pregnant or lactating women
• Individuals with allergies to iron or dextran
• Individuals with a history of cirrhosis

Where it is running

• Joslin Diabetes Center — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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