Assessment of Cardiac Functional Reserve in Heart Failure With Preserved Ejection Fraction (HF-PEF)

Completed

Conditions studied: Heart Failure

In brief

This study will compare the ability of the heart to increase its contractile performance during stress in patients with a history of heart failure without systolic dysfunction and in controls.

Key facts

Study ID

NCT00585806

Run by

University of Wisconsin, Madison

People needed

19

Starts

2005-12-01

Expected to finish

2009-06-01

Last updated by the study team

2015-10-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• mentally stable and willing to give informed consent
• sinus rhythm on resting ECG
• systolic blood pressure > 90 mmHg
• ejection fraction > 45% assessed within the last year
• stable heart failure for at least one month prior to study

You may not qualify if…

• unstable angina or hemodynamic instability
• known severe coronary artery disease without surgical or percutaneous revascularization
• angina pectoris with usual activities
• history of myocardial infarction in the previous six months, significant valvular abnormalities, pulmonary hypertension, COPD or pulmonary emboli, intracardiac thrombus, sustained ventricular tachycardia induced by dobutamine in the past, or known allergy or other intolerance to dobutamine
• uncontrolled hypertension
• pregnant women
• permanent pacemaker with pacemaker dependency
• known poor echocardiographic images

Where it is running

• University of Wisconsin Hospital and Clinics — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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