Mannitol Bronchoprovocation Challenge Ancillary Study/ACRN

Completed · Early Phase 1

Conditions studied: Asthma

In brief

This is an ancillary study conducted as part of the BASALT trial \[NCT00495157\]. The overall hypotheses are: 1) an indirect airway challenge procedure using mannitol can safely characterize asthma phenotypes, predict asthma control and exacerbations, predict responses to interventions, and perform more specifically than a direct methacholine challenge and; 2) PX27 pore function in whole blood correlates with measures of airway hyperresponsiveness induced by methacholine and/or mannitol challenges

Key facts

Study ID

NCT00585260

Run by

University of Wisconsin, Madison

People needed

66

Starts

2007-12-01

Expected to finish

2010-02-16

Last updated by the study team

2019-08-19

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• all subjects randomized to the BASALT protocol

You may not qualify if…

• positive urine pregnancy test
• requirement for more than two albuterol treatments for reversal of the methacholine bronchoprovocation challenge procedure at visit 4 in the BASALT parent trial

Where it is running

• University of Wisconsin Madison Department of Asthma, Allergy and Pulmonary Clinical Research — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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