Albuterol Versus Xopenex in Treatment of Acute Asthma in the Emergency Department (ED)

Completed · Phase 4

Conditions studied: Asthma

In brief

The purpose of this study is to determine in a large, double-blind, randomized, prospective pediatric clinical trial whether the use of continuous levalbuterol (Xopenex) in addition to standard emergency department treatment for acute asthma exacerbations will improve the Forced Expiratory Volume in 1 sec (FEV 1) compared to the use of continuous racemic albuterol. The secondary objective is to correlate clinical (hospitalization rates and clinical asthma scores) with plasma levels of (S)-albuterol.

Key facts

Study ID

NCT00585039

Run by

Phoenix Children's Hospital

People needed

101

Starts

2005-09-01

Expected to finish

2009-03-01

Last updated by the study team

2026-02-10

Who can join

Age: 6 and older, up to 17. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient is between the ages of 6 and 17
• Has previously been diagnosed with asthma by any physician
• Has presented to the ED with an asthma exacerbation judged by a physician to be of a moderate or severe degree

You may not qualify if…

• Requires immediate resuscitation (attending physician)
• Is pregnant and/or breast feeding
• If possibly pregnant, negative pregnancy test attached
• Has chronic lung diseases (i.e. cystic fibrosis)
• Has an uncorrected congenital heart diseaseHas a suspected foreign body aspiration
• Is allergic to albuterol and/or levalbuterol (Xopenex)
• Has an initial FEV 1>70% predicted

Where it is running

• Phoenix Children's Hospital — Phoenix, Arizona, United States

Full record on ClinicalTrials.gov

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