Clinical Trial Evaluating Rituximab in Ocular Cicatricial Pemphigoid

Completed · Phase 1/Phase 2

Conditions studied: Ocular Cicatricial Pemphigoid

In brief

Cicatricial pemphigoid is an autoimmune blistering disease which affects the skin, mucous membranes, and, in a small subset of patients, the eye. Progressive ocular disease can lead to irreversible damage and blindness. Conventional treatments include systemic steroids, dapsone, and immunosuppressive agents. These treatments, however, are not successful with all patients. Rituximab has been very effective in the treatment of other autoimmune disorders, and has recently been shown to be effective for autoimmune blistering pemphigus. We propose that it will also be effective in the treatment of cicatricial pemphigoid.

Key facts

Study ID

NCT00584935

Run by

University of Alabama at Birmingham

People needed

3

Starts

2006-01-01

Expected to finish

2026-01-01

Last updated by the study team

2026-05-04

Who can join

Age: 19 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Clinical diagnosis of ocular cicatricial pemphigoid (symptoms of conjunctivitis, irritation, burning, increased lacrimation, photophobia, dryness of the eyes along with conjunctival inflammation, trichiasis, and scarring
• One of the following:
• Failed response to the use of one or more conventional treatments for a minimum of 10 weeks; or
• Minimal conventional medication doses, with a significant adverse effects, contradiction to use, or progressive disease despite treatment
• Adults age 19 and older
• Adequate renal function as indicated by serum creatinine levels less than 1.5

You may not qualify if…

• known hypersensitivity to rituximab or its components
• Age less than 19 years
• Any other condition deemed by the investigator to be a significant hazard to the subject if the investigational therapy were initiated.

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.