Assessment of Cough Reflex in Lung Transplant Recipients

Completed

Conditions studied: Complication of Transplanted Lung

In brief

The purpose of this study is to evaluate the presence of cough reflex in the transplanted lung of patients who have had either a single or double lung transplant or heart-lung transplant at University of Texas Medical Branch. At the 1 year post transplant bronchoscopy, the presence of the cough reflex will be assessed by placing 3 to 5 ml of 5% dextrose and placement of the bronchial biopsy forceps on the airway mucosa. Three to four separate areas of the transplanted airways will be assessed. The cough reflex will be assessed by recording the surface electrical activity by placing external electrodes to monitor the movement of abdominal muscles during a cough. The data will be recorded and compared with recordings from coughs recorded using the surface electrical activity of a cough generated by non-transplant patients.

Key facts

Study ID

NCT00584077

Run by

The University of Texas Medical Branch, Galveston

People needed

15

Starts

2000-04-01

Expected to finish

2007-10-01

Last updated by the study team

2018-11-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Lung transplant recipient
• Hemodynamically stable
• Capable of undergoing bronchoscopy

You may not qualify if…

• Pneumonia
• Hypoxemia (PaO2 < 70)
• Hemodynamic instability
• Coagulopathy
• Thrombocytopenia

Where it is running

• University of Texas Medical Branch — Galveston, Texas, United States

Full record on ClinicalTrials.gov

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