Trental & Vitamin E for Radiation-Induced Fibrosis

Completed · Phase 2

Conditions studied: Fibrosis

In brief

This study seeks to determine if a combination of Trental and Vitamin E prevents the development of radiation fibrosis in women treated with radiation for the definitive management of their breast cancer.

Key facts

Study ID

NCT00583700

Run by

University of Iowa

People needed

54

Starts

2003-02-01

Expected to finish

2012-06-01

Last updated by the study team

2013-01-29

Who can join

Age: 20 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with histologically documented cancer of the breast or DCIS or head and neck referred for definitive radiation with curative intent.
• No evidence of metastatic disease.
• Minimum life expectancy of at least 12 months.
• Aged greater than 20 years.
• If female, pregnancy excluded.
• No documented history of collagen vascular disease.

You may not qualify if…

• Cognitively impaired patients
• Prisoners
• No histology available
• Documented metastatic disease
• Allergy to Trental
• Life expectance of less than 12 months.
• Aged less than 20 years
• Collagen vascular disease present
• Pregnant
• History of liver disease
• Use of anticoagulants

Where it is running

• The University of Iowa Hospitals & Clinics — Iowa City, Iowa, United States

Full record on ClinicalTrials.gov

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