Does Omeprazole Decrease Intestinal Calcium Absorption?

Completed · Phase 4

Conditions studied: Osteoporosis, Achlorhydria, GERD, Hip Fracture

In brief

The purpose of this study is to measure the effect of omeprazole on intestinal calcium absorption in postmenopausal women.

Key facts

Study ID

NCT00582972

Run by

University of Wisconsin, Madison

People needed

23

Starts

2008-01-01

Expected to finish

2010-12-01

Last updated by the study team

2013-02-15

Who can join

Age: any. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Women at least 5 years past menopause, defined as the last date of menses

You may not qualify if…

• Allergy/Intolerance to orange juice
• Allergy/Intolerance to omeprazole or other PPI therapy
• Use of drugs that interact with omeprazole including oral anti-fungal agents, coumadin, diazepam, phenytoin \& tacrolimus
• Use of antacids, PPI or H2-blocker therapy within the past two months
• Intestinal conditions associated with malabsorption or low gastric acid levels including Crohn's Disease, ulcerative colitis, pernicious anemia, bacterial overgrowth, celiac sprue, chronic diarrhea or use of antibiotics within the past month
• Known Stage 4 or 5 Chronic Kidney Disease, defined as an estimated GFR <30 cc/minute
• Use of medications known to interfere with calcium metabolism, including oral steroids or anticonvulsants

Where it is running

• University of Wisconsin Hospital and Clinics — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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