Depression, Cytokines and Pancreatic Cancer

Completed

Conditions studied: Pancreatic Cancer

In brief

The purpose of this study is to measure certain specific chemicals in your blood, produced by the body in response to a stress, such as having pancreatic cancer. These chemicals are called "cytokines" and the researchers doing this study want to look at the role they may play in developing depression.

Key facts

Study ID

NCT00582699

Run by

Memorial Sloan Kettering Cancer Center

People needed

80

Starts

2005-11-01

Expected to finish

2014-04-01

Last updated by the study team

2014-04-10

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 40 years of age or older at the time of recruitment.
• Unresectable/inoperable pancreatic adenocarcinoma (stage III or IV), receiving Gemcitabine or Gemcitabine-based combination therapy.
• If in the "depressed" sample, patients with pancreatic cancer must meet DSM-IV criteria for a major depressive syndrome (based on the SCID) AND have an HDRS score of 18 or greater.
• If in the "non-depressed" sample, patients with pancreatic cancer must not meet DSM-IV criteria for a major depressive syndrome (based on the SCID) AND must have a HDRS score of 17 or less.

You may not qualify if…

• A. Patient has reported experiencing or medical record indicates a serious medical event (i.e.,medical hospitalization (excluding hospitalization related to cancer diagnosis/treatment),myocardial infarction, stroke) within the year preceding study participation.
• B. Patient has reported the presence of or medical record indicates:
• Type 1 Diabetes, unrelated to cancer diagnosis
• renal failure requiring dialysis
• inflammatory bowel disease 3. Patient has reported the presence of or medical record indicates an active secondary cancer diagnosis, however patients who have been treated for a past cancer and are 2 years disease free from that cancer can participate.
• Presence of a medical/surgical condition obtained through self-report associated with elevated cytokine levels, such as:
• HIV/AIDS
• Auto-immune diseases such as SLE, Multiple Sclerosis, Rheumatoid Arthritis, Polymyalgia Rheumatica, Temporal Arteritis, Chronic Fatigue Syndrome, severe allergies
• Congestive Heart Failure
• Recent stroke
• Alzheimer's Disease
• Active infection;
• Acute pancreatitis
• Acute pericarditis
• Acute hepatitis including Hepatitis C
• Recent vaccination for viral disease
• Major surgery within the past 6 weeks
• Patient Reports Receiving treatment (within two weeks) with:
• Interleukin
• Interferon
• Thalidomide
• NSAID's
• Cox-2 inhibitors
• Cancer vaccine therapies
• Self-reported diagnosis with a major psychiatric disorder other than depression (e.g. psychosis secondary to Bipolar Disorder, Schizophrenia, Schizo-affective illness, substance abuse) so severe that, in the opinion of the study staff, would interfere with a patient's ability to give informed consent for research.

Where it is running

• Memorial Sloan-Kettering Cancer Center — New York, New York, United States

Full record on ClinicalTrials.gov

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