Comparative Trial Between 3 Types of Insulin Infusion Protocols
Completed · Not applicable
Conditions studied: Hyperglycemia
In brief
Increasing evidence from observational studies in hospitalized patients with and without diabetes indicates that hyperglycemia is a predictor of poor outcome. Over the short-term, hyperglycemia can adversely affects fluid balance (through glycosuria and dehydration), impairs immunologic response to infection, and promotes inflammation and endothelial dysfunction. Blood glucose control with intensive insulin therapy in patients with acute critical illness reduces the risk of multiorgan failure and systemic infections, and decreases short- and long-term mortality . \- Hypotheses: we hypothesize that management of inpatient hyperglycemia with a computer-guided intravenous infusion protocol (Glucommander) will facilitate a smoother glycemic control with a lower rate of hypoglycemic events than treatment following a standard insulin infusion algorithm or a simple calculated infusion protocol in critically ill patients in the medical and surgical ICU.
Key facts
- Study ID
- NCT00582309
- Run by
- University of New Mexico
- People needed
- 151
- Starts
- 2007-08-01
- Expected to finish
- 2008-12-01
- Last updated by the study team
- 2015-06-23
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients who are admitted to Medical or Surgical ICU.
- History of diabetes mellitus
- Newly diagnosed hyperglycemia (defined as a blood glucose greater than 140 mg/dl on ≥ 2 occasions)
- Subjects must have an admission blood glucose < 500 mg/dL, without laboratory evidence of diabetic ketoacidosis (serum bicarbonate < 18 mEq/L or positive serum or urinary ketones).
You may not qualify if…
- Non-Diabetic patients
- Subjects with acute hyperglycemic crises such as diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state.
- Patients with known HIV
- Patients with severely impaired renal function (serum creatinine ≥3.0 mg/dl).
- Patients with mental condition rendering the subject unable to understand the nature, scope, and possible consequences of the study.
- Female subjects who are pregnant or breast feeding at time of enrollment into the study
Where it is running
- St. James Hospital and Health Centers — Chicago Heights, Illinois, United States
- Presbyterian Hospital — Albuquerque, New Mexico, United States
- University of New Mexico Hospital — Albuquerque, New Mexico, United States
Full record on ClinicalTrials.gov
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