Cognitive Functioning and Quality of Life in CNS Lymphoma

Completed

Conditions studied: Lymphoma, Central Nervous System Lymphoma

In brief

The purpose of this study is to evaluate several aspects of thinking abilities including attention and memory, and quality of life in patients who were diagnosed with and treated for Primary CNS Lymphoma (PCNSL), and are in remission of their disease. The findings of this study may help us understand whether this disease and its treatment may have affected some patients' thinking skills, and may provide important information that can be used to develop programs to improve the quality of life of patients with PCNSL. This research will also study whether persons having particular types of genes involved in the metabolism of methionine (5-methyltetrahydrofolate-homocysteine S-methyltransferase-MTR, MTFH reductase-MTFHR, transcobalamin 2-Tc2), and apolipoprotein E (APOE) are more likely to have delayed adverse effects after treatment for their tumors. The findings of this study may help us understand whether this disease and its treatment may have affected some patients' thinking skills, and whether this may be related to having certain genes.

Key facts

Study ID

NCT00581737

Run by

Memorial Sloan Kettering Cancer Center

People needed

50

Starts

2000-07-01

Expected to finish

2009-08-01

Last updated by the study team

2012-03-05

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of and treatment for PCNSL
• Disease in remission at the time of testing, as defined by negative MRI and/or CSF cytology, and ocular exam if initially positive
• English speaking

You may not qualify if…

• patients who are medically unstable
• patients with severe, decompensated psychiatric disorders
• patients with a pre-existing neurological condition other than the designated illness (e. g., head trauma)

Where it is running

• Memorial Sloan-Kettering Cancer Center — New York, New York, United States

Full record on ClinicalTrials.gov

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