Role of Adenosine in the Release of VEGF and Cytokines
Stopped early · Phase 1
Conditions studied: Inflammation
In brief
The purpose of this study is to extend previous observations in animal models regarding the effects of adenosine in the release of cytokines to human subjects. We intend to accomplish this in two study protocols. In the first we will infuse intravenously adenosine and measure the plasma levels of inflammatory cytokines. In the second one, we will use a microdialysis technique to infuse intradermally small amounts of adenosine and will measure skin blood flow and will take a biopsy to measure levels of mRNA for cytokines.
Key facts
- Study ID
- NCT00580905
- Run by
- Vanderbilt University
- People needed
- 8
- Starts
- 2007-06-01
- Expected to finish
- 2017-01-01
- Last updated by the study team
- 2018-02-28
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age 18-60 yr.
- All potential volunteers will have routine blood test to screen for hepatic, renal, and hematological abnormalities.
- Body mass index < 27 Kg/m2 .
- Female volunteers of childbearing potential will undergo HCG pregnancy test at screening and again on the study day.
You may not qualify if…
- Pregnancy females
- Subjects unable to give voluntary informed consent
- Subjects on anticoagulant drugs or anemic
- Subjects with a recent medical illness
- Subjects with a history of coronary heart disease
- Subjects with known kidney or liver disease
- Subjects with history of asthma
- Recent (past three days) use of phosphodiesterase type 5 (PDE5) inhibitors (sildenafil, tadalafil or vardenafil)
- History of intolerance to adenosine or nitroprusside
- History of methemoglobinemia
- Use of theophylline products
- Subjects with hematological abnormalities
Where it is running
- Vanderbilt University Medical Center — Nashville, Tennessee, United States
Full record on ClinicalTrials.gov
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