The Effect of Varenicline (Chantix) and Bupropion (Zyban) on Smoking Lapse Behavior

Completed · Phase 2 · Has a placebo group

Conditions studied: Smoking Lapse Behavior

In brief

The purpose of this study is to examine how smoking cessation medications (varenicline, bupropion) affect the ability to resist smoking and also subsequent ad-lib smoking in non-treatment seeking daily smokers.

Key facts

Study ID

NCT00580853

Run by

Yale University

People needed

62

Starts

2007-04-01

Expected to finish

2016-10-01

Last updated by the study team

2018-02-08

Who can join

Age: 21 and older, up to 55. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ages 18-55
• able to read and write in English
• Smokers

You may not qualify if…

• any significant current medical or psychiatric conditions that would contraindicate smoking
• current Diagnostic and Statistical Manual IV abuse or dependence of other substances, other than nicotine dependence or alcohol abuse
• positive test result at intake appointments on urine drug screens conducted for opiates, cocaine, or benzodiazepines
• women who are pregnant or nursing
• suicidal, homicidal, or evidence of current severe mental illness
• participants prescribed any psychotropic drug in the 30 days prior to study enrollment
• blood donation within the past 6 weeks
• individuals seeking treatment for smoking cessation or have attempted to quit smoking within the past 3 months
• specific exclusions for bupropion administration not already specified, including: have taken monoamine inhibitors in the past 6 weeks; history of anorexia or bulimia; previous hypersensitivity to bupropion; history of alcohol or drug dependence in the past year; history of seizure disorder of any etiology
• known allergy to varenicline or taking H2blockers
• participation within the past 8 weeks in other studies that involve additive blood sampling and/or interventional measures that would be considered excessive in combination with the current study

Where it is running

• Yale Center for Clinical Investigation, Yale University — New Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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