A Pilot Study of Switching From One Pain Medication to Another (Opioid Rotation)
Completed · Not applicable
Conditions studied: Pain
In brief
The purpose of this study is to see if changing from one pain medication like morphine or oxycodone to another pain medication, oxymorphone (OPANA®), will be helpful to patients. This study will examine if the switching from one pain medication to another can be done over a 24 hour period. Oxymorphone, the drug being studied, is an FDA approved drug for treatment of severe pain.
Key facts
- Study ID
- NCT00580294
- Run by
- Icahn School of Medicine at Mount Sinai
- People needed
- 12
- Starts
- 2007-11-01
- Expected to finish
- 2008-08-01
- Last updated by the study team
- 2016-02-03
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age of 18 to no upper limit
- Chronic pain of nociceptive, neuropathic, or mixed origin
- Patients with chronic non cancer pain
- Ongoing chronic opioid treatment with either oral morphine or oxycodone (long term - more than 3 months of at least a total daily opioid dose of 60 mg morphine or of 30 mg oxycodone)
- Pain of moderate intensity (>4, on the numerical scale 0-10) despite ongoing opioid therapy>
- Non-pregnant, non-lactating women
- Sufficient language skills to communicate with research staff
- Exclusion Criteria:Non-ambulatory patients
- Clinically significant respiratory, renal, hepatic, or cardiac disease.
- Documented diagnosis of sleep apnea (the study physician may exclude patients who present with clinical features and complaints suggestive of a diagnosis of probable sleep apnea)
- History of illicit drug or alcohol dependence or abuse, abnormal drug taking / seeking behaviors
- Severe depression (> 26 on the BDI)
- Patients who exhibit a score on the Mini Mental Status Exam (MMSE) of 26 or less. (The range of scores for mild dementia is 21-26 on the MMSE).
- Workman compensation, current or pending medical-legal litigation
- Hypersensitivity to study medication (oxymorphone)
Where it is running
- Icahn School of Medcine at Mount Sinai — New York, New York, United States
Full record on ClinicalTrials.gov
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