Registry for Patients With Acquired Resistance to Small Molecule Kinase Inhibitors in Non-Small-Cell Lung Cancer

Completed

Conditions studied: Unresectable or Metastatic Non-small Cell Lung Cancer (NSCLC)

In brief

The purpose of this study is to try to learn more about how small molecule kinase inhibitors work in treating lung cancer. Some early studies have shown that gefitinib, erlotinib and similar drugs are more likely to work if a particular DNA change (also known as a mutation) is found in a protein that is important in lung cancer. This protein is called the epidermal growth factor receptor (EGFR). Since small molecule kinase inhibitors sometimes stop working, we would like to examine your tumor to learn why these medicines are not working as well. Your tumor will be examined for a variety of things including changes in the DNA of the EGFR. We will also sequence parts of the genes for HER2, HER3, HER4, and KRAS, other proteins thought to be important in lung cancer.

Key facts

Study ID

NCT00579683

Run by

Memorial Sloan Kettering Cancer Center

People needed

228

Starts

2004-08-01

Expected to finish

2016-02-01

Last updated by the study team

2016-02-04

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients diagnosed with unresectable or metastatic non-small cell lung cancer (NSCLC) and who fulfill the following eligibility criteria will be considered eligible for this study.
• Patient must have previously received treatment with small molecule kinase inhibitors targeting at least, in part, EGFR patients may have received other treatments since treatment with small molecule kinase inhibitors including radiation or chemotherapy)
• Development of disease progression while actively receiving tyrosine kinase inhibitor
• Signed informed consent

You may not qualify if…

• None

Where it is running

• Memoral Sloan Kettering Cancer Center — Basking Ridge, New Jersey, United States
• Memorial Sloan-Kettering Cancer Center @ Suffolk — Commack, New York, United States
• Memorial Sloan Kettering Cancer Center — New York, New York, United States
• Memorial Sloan-Kettering at Mercy Medical Center — Rockville Centre, New York, United States
• Memoral Sloan Kettering Cancer Center at Phelps — Sleepy Hollow, New York, United States

Full record on ClinicalTrials.gov

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