Markers of Inflammation in Hematopoietic Stem Cell Transplant

Completed

Conditions studied: Acute Graft Versus Host Disease

In brief

Objectives: 1. To show feasibility and reproducibility of performing a multiplex ligation-dependent amplification procedure (RT-MLPA) 2. To describe the profile of changes in inflammatory gene products, using RT-MLPA, in pediatric patients receiving stem cell transplant 3. To determine if changes in a specific inflammatory product, or a combination of inflammatory products, can predict grade 2-4 acute graft-versus-host disease

Key facts

Study ID

NCT00579397

Run by

Ann & Robert H Lurie Children's Hospital of Chicago

People needed

30

Starts

2007-04-01

Expected to finish

2012-12-12

Last updated by the study team

2019-08-30

Who can join

Age: any, up to 21. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Objective #1:
• Healthy adult volunteers, affiliated to Children's Memorial Hospital
• Male or female
• Objective #2 \& #3:
• Recipient undergoing an allogeneic stem cell transplant
• Receiving related or unrelated cord blood, related or unrelated bone marrow or peripheral blood stem cells
• Any pre-transplant regimen
• Ages of 0-21 years old
• Male or female

You may not qualify if…

• Inability for subject/parent to understand study and therefore unable to consent
• Children under 7.0 kgs

Where it is running

• Lurie Children's Hospital — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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