Allogeneic Bone Marrow Transplantation for the Treatment of Genetic Disorders of Erythropoiesis

Completed · Phase 2

Conditions studied: Genetic Disorders, Sickle Cell Anemia

In brief

The purpose of this study is to determine and confirm the role of bone marrow transplantation in the treatment of disorders of the red cell and hemoglobin including sickle cell anemia, thalassemia and diamond blackfan anemia.

Key facts

Study ID

NCT00578435

Run by

Memorial Sloan Kettering Cancer Center

People needed

25

Starts

1994-01-01

Expected to finish

2008-08-01

Last updated by the study team

2008-09-12

Who can join

Age: 1 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with severe HOMOZYGOUS SICKLE CELL ANEMIA or SICKLE/BETA THALASSEMIA
• Neurologic event (stroke or hemorrhage).
• Abnormal cerebral MRI scan and cerebral arteriogram or MRI angiographic study (MRA) and impaired neuropsychologic testing.
• Recurrent acute chest syndrome (> 2 episodes)
• Stage I-II sickle chronic lung disease
• Sickle cell nephropathy (moderate or severe proteinuria or GFR 30-50% of predicted for age.
• Major visual impairment in at least one eye with bilateral proliferative retinopathy.
• Osteonecrosis of multiple bones
• Chronic debilitating pain secondary to vasoocclusive crisis (>= 3 episodes per year for >= 3 years) Recurrent priapism
• Allo-immunization with the development of antibodies following chronic transfusion therapy
• Patients with HOMOZYGOUS SICKLE CELL ANEMIA or SICKLE/BETA THALASSEMIA with the following criteria will be considered for accrual on this protocol
• Patients < 2 years with high WBC counts and/or >1 episode of dactylitis and/or a Hgb < 7 g/dl
• History of death from sickle cell disease in sibship of patient
• Patients with BETA-THALASSEMIA MAJOR with Lucarelli class 1 or 2 risk status i.e with only 0-2 of the following factors: hepatomegaly, portal fibrosis, or poor chelation therapy
• Patients with DIAMOND-BLACKFAN ANEMIA who have failed conventional therapy.
• Patients must have an HLA-compatible related donor. The donor must be healthy and able to undergo general anesthesia. Donors with heterozygous sickle cell anemia (hemoglobin AS) or with heterozygous thalassemia are acceptable donors.
• At the time of referral for transplantation, patients must be in good clinical condition without any evidence of infections and a Karnofsky or Lansky pediatric performance scale > 70%
• Each patient and donor must be willing to participate as a research subject and must sign an informed consent form after having been advised as to the nature and risk of the study prior to entering the protocol. Parents or legal guardians of patients who are minor will sign the consent form after being advised of the nature and risks of the study

You may not qualify if…

• Patients whose life expectancy is less than 8 weeks. Patients with a Karnofsky or Lansky performance score of < 70%
• Patients with severe major organ dysfunction:
• Patients with severe renal impairment. This will be determined by a creatinine clearance < 70 ml/min/1.73 m2 (or serum creatinine > 1.5 x Normal) or by a glomerular filtration rate < 30% of predicted normal for age
• Inadequate cardiac function as determined by fractional shortening < 28% on echocardiogram, and/or ejection fraction of < 50% on echocardiogram or RNCA.
• Patients with FS of 23-28% who show an increase in FS in response to stress on the supine bicycle ergometer are eligible
• Major liver dysfunction: SGOT > 3 x upper limit of normal. Hyperbilirubinemia will not be used as an exclusion criteria because of the hemolytic component of the bilirubin. Patients with active hepatitis or severe liver fibrosis will also be excluded
• Severe residual functional neurologic impairment
• Stage III-IV sickle chronic lung disease
• Pregnant or lactating women are excluded

Where it is running

• Memorial Sloan-Kettering Cancer Center — New York, New York, United States

Full record on ClinicalTrials.gov

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