Bevacizumab and Carboplatin/Paclitaxel and Radiation in Non-Small Cell Lung Cancer
Completed · Phase 2
Conditions studied: Non-Small Cell Lung Cancer
In brief
This study is being done to learn what effects (good and bad) bevacizumab in conjunction with carboplatin/paclitaxel and radiation therapy has on patients with non-small cell lung cancer (NSCLC).
Key facts
- Study ID
- NCT00578149
- Run by
- Dana-Farber Cancer Institute
- People needed
- 45
- Starts
- 2006-05-01
- Expected to finish
- 2007-08-01
- Last updated by the study team
- 2007-12-21
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Histologically confirmed non-small cell lung cancer (NSCLC) that have been evaluated and determined not to be candidates for surgical resection as part of their definitive management of stage III disease.
- Age 18 years or older
- ECOG performance status of 0-1
- Life Expectancy of greater than six months
- Normal organ and marrow function
- Women and men of child-bearing potential must agree to use adequate contraception
You may not qualify if…
- Prior chemotherapy or thoracic radiation therapy
- Squamous histology or any histology in close proximity to a major vessel
- Active hemoptysis
- History of hypercoagulability
- Known distant metastatic disease
- History of allergic reactions attributed to compounds with similar chemical or biological composition to bevacizumab, carboplatin, paclitaxel or other agents used in this study
- Patients with uncontrolled intercurrent illness
- Pregnant women
- Major surgical procedure, open biopsy, or significant traumatic injury with in 28 days prior to day 0
- Minor surgical procedure within 7 days to day 0
- HIV-positive patients receiving combination anti-retroviral therapy.
- Non-skin cancer malignancy in the past 5 years.
Where it is running
- Massachusetts General Hospital — Boston, Massachusetts, United States
- Dana-Farber Cancer Institute — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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