A Pilot Study to Measure Blood Levels of Desflurane in Children

Completed · Not applicable

Conditions studied: Desflurane Levels

In brief

In this feasibility study we will collect blood from indwelling arterial catheters in up to 20 patients undergoing non-emergent surgery with desflurane anesthesia at Children's Hospital of Philadelphia. Desflurane levels will be determined by high pressure liquid chromatography (HPLC). Our eventual goal is to quantify fetal levels of desflurane in umbilical cord blood during fetal surgery. We propose a pilot study to assess the ability of our assay to measure desflurane in human blood.

Key facts

Study ID

NCT00577369

Run by

Children's Hospital of Philadelphia

People needed

7

Starts

2007-12-01

Expected to finish

2008-06-01

Last updated by the study team

2009-09-16

Who can join

Age: 1 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Children between 1 and 18 years old
• Weight >10 kg
• Scheduled for elective surgery
• Patient will have an arterial catheter placed as routine care for the surgery
• Informed consent (and assent if applicable)

You may not qualify if…

• Desflurane not used as part of anesthetic
• Preoperative hemoglobin less than 9 mg/dl
• Any investigational drug use within 30 days prior to enrollment
• Pregnant or lactating females

Where it is running

• The Children's Hospital Of Philadelphia — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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