Genomic Tools for Studying the Ecology of the Human Vaginal Microflora
Completed
Conditions studied: Healthy
In brief
The human vagina contains a large number of normal bacteria. These bacteria are important because provide protection against other bacteria that may cause disease. Several important diseases are linked to abnormal bacteria in the vagina. Women with abnormal bacteria in the vagina are more likely to be infected with human immunodeficiency virus, the virus that causes AIDS. Also women with unusual bacteria in their vagina are more likely to deliver a premature baby when they are pregnant. For these reasons, it is important to have a better understanding of the normal bacteria of the vagina.Some bacteria found in the vagina can not be grown in a laboratory. Our preliminary studies indicate a very wide variety of bacteria in the vagina. Also we have shown there are some differences between African American and Caucasian women. The goal of our study is to study the bacteria in the vagina of normal women using the latest technology. This technology involves study the bacterial DNA present in the normal microbes in the vagina
Key facts
- Study ID
- NCT00576797
- Run by
- Emory University
- People needed
- 396
- Starts
- 2008-05-01
- Expected to finish
- 2009-01-01
- Last updated by the study team
- 2016-02-02
Who can join
Age: 12 and older, up to 45. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Between the ages of 12 and 45
- Regular menstrual cycles from 21 to 35 days long
- Normal healthy volunteer
- Negative urine pregnancy test
- Ability to understand and sign informed consent
You may not qualify if…
- Used douches, vaginal medications or suppositories, feminine sprays, genital wipes, or contraceptive spermicides in the past 48 hours
- Sexually active in the past 48 hours (involving female genitalia)
- Pregnancy (by history or testing)
- Use of antibiotics or antifungal drugs within the past 30 days
- Have chronic illnesses such as kidney failure, diabetes or HIV/AIDS
- Self-reported vaginal discharge in the past 48 hours
- Currently menstruating
- Currently participating in a drug or treatment clinical research trial
- Received a vaccine within the last 30 days
- Received a vaccine against a bacterial infection
- Currently using NuvaRing for contraception
- Any other condition that in the opinion of the investigator would place the subject in unacceptable risk for participation in the study
Where it is running
- Emory University — Atlanta, Georgia, United States
- Adolescent and Young Adult Center (AYAC),UMB — Baltimore, Maryland, United States
- Center for Vaccine Development, University of Maryland — Baltimore, Maryland, United States
Full record on ClinicalTrials.gov
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