Evaluation of Atorvastatin on Atherosclerosis Composition

Completed · Not applicable

Conditions studied: Atherosclerosis

In brief

The purpose of this study is to evaluate the effects of Atorvastatin on the coronary atherosclerosis plaque morphology.

Key facts

Study ID

NCT00576576

Run by

Emory University

People needed

27

Starts

2007-07-01

Expected to finish

2010-03-01

Last updated by the study team

2013-12-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• The patients are eligible if they are undergoing catheterization for stable angina or acute coronary syndromes
• At the time of catheterization the patient has a "moderate coronary" lesion in the proximal 60mm of an epicardial coronary artery
• "Moderate lesion" is defined as a lesion deemed significant enough to warrant further evaluation using coronary flow reserve (CFR) and fractional flow reserve (FFR) by the treating physician
• Patient must have decision making capacity and consented prior to the catheterization
• Ages: All ages
• Performance Status: all levels

You may not qualify if…

• Screening Exclusion Criteria:
• Patients with coronary bypass grafts
• Severe valvular heart disease
• Patients presenting with a ST segment elevation myocardial infarction (STEMI)
• Inability to provide informed consent prior to randomization
• Creatinine >1.5
• Patients who are on a statin with an LDL < 130.
• Any patient on a maximum dose of statin (atorvastatin 80mg, simvastatin 80mg, rosuvastatin 20mg, pravastatin 80mg, or fluvastatin 80mg)
• Uncontrolled diabetes requiring intensification of therapy
• Uncontrolled hypertension requiring the addition of angiotensin-converting enzyme inhibitor or angiotensin receptor blocker
• Angiographic Ineligibility Criteria:
• A Left Main lesion greater than 50% stenosis
• The moderate lesion is located beyond 60mm
• Collaterals
• Coronary Anatomy requiring coronary artery bypass grafting (CABG)

Where it is running

• Emory University Hospital — Atlanta, Georgia, United States

Full record on ClinicalTrials.gov

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