Novel Imaging Techniques in Barrett's Esophagus

Completed · Not applicable

Conditions studied: Barrett Esophagus, Gastroesophageal Reflux

In brief

Primary Aim: In patients with endoscopically suspected BE, compared to standard endoscopy, novel techniques (NBI and AFI) with target biopsies will * Detect more patients with intestinal metaplasia * Detect more areas of high grade dysplasia * Require fewer biopsies and a shorter time for procedure completion Secondary Aim: * Compare the yield of high-grade dysplasia(HGD)using NBI/AFI versus standard endoscopy with biopsy. * Compare the number of biopsies and procedure times for NBI/AFI versus standard endoscopy with biopsy. * Compare the inter-observer variability in classifying different mucosal and vascular patterns observed by NBI/AFI using kappa statistics.

Key facts

Study ID

NCT00576498

Run by

Midwest Biomedical Research

People needed

130

Starts

2005-10-01

Expected to finish

2009-05-01

Last updated by the study team

2012-10-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with suspected Barrett's esophagus on endoscopy
• Age > 18 years
• Ability to provide written informed consent

You may not qualify if…

• Presence of erosive esophagitis
• Visible nodules, lesions within Barrett's esophagus segment
• Endoscopist aware of biopsy results
• Inability to obtain biopsies due to anticoagulation or varices

Where it is running

• Veterans Affairs Medical Center — Kansas City, Missouri, United States
• Medical University of South Carolina — Charleston, South Carolina, United States
• Academisch Medisch Centrum-Universiteit van Amsterdam (AMC-UvA) — Amsterdam, Netherlands

Full record on ClinicalTrials.gov

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