Measurement of Matrix Metalloproteinase Activation Post Myocardial Infarction

Withdrawn before enrolling

Conditions studied: Acute Myocardial Infarction

In brief

This study is designed to look at the measurement and prediction of changes in the heart following a heart attack.

Key facts

Study ID

NCT00576121

Run by

Yale University

People needed

0

Starts

2008-07-01

Expected to finish

2012-08-01

Last updated by the study team

2016-06-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of acute myocardial infarction characterized by (1) greater than 30 minutes of chest pain; (2) ST elevation in 2 contiguous leads greater than 2mV; and (3) elevated serum markers greater than three times the normal value.
• Males or females 18 years of age or older.
• Adequate intravenous access in one arm.
• Willing to comply with the requirements of the protocol.
• Provided written informed consent to participate in the study.

You may not qualify if…

• History of significant co-morbidity requiring hospitalization separate from acute myocardial infarction (i.e. metastatic cancer).
• History of/current structural heart disease.
• Arrhythmia
• History of previous myocardial infarction
• History of coronary revascularization
• Cardiogenic shock
• Hypotension
• Renal failure (creatinine >2mg/dl) or hyperkalemia (serum potassium > 5.5mg/dl)
• History of allergic reaction to gadolinium
• Contraindication to undergo MR imaging (pacemaker, metallic implants, etc)
• History of claustrophobia
• Pregnant or breast-feeding, or (if pre-menopausal), not practicing acceptable method of birth control.
• History of any other conditions, which in the judgment of the investigator, are likely to hinder or confuse study conduct or to pose a safety concern to the patient.
• Resting HR >110
• Chronic tetracycline or doxycycline use
• Ongoing/active rheumatic disease requiring significant anti-inflammatory agents, steroids or immunosuppression
• Not capable of informed consent

Where it is running

• Yale New Haven Hospital — New Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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