Antiretrovirals and Rate of Progression in Carotid Artery Intima-medial Thickness in HIV
Completed
Conditions studied: HIV Infections, Atherosclerosis
In brief
It is well known that HIV-infected subjects frequently experience hyperlipidemias, insulin resistance, and visceral adiposity, which are known to increase the risk of atherosclerosis. Several cohorts have shown an increased risk of heart disease in people with HIV. The effect of HIV treatment versus HIV itself on the incidence of heart disease is unclear. In this study the investigators will assess the effect on carotid IMT of the initiation of antiretroviral combinations that are known to have a minimal effect on lipids and insulin resistance. We will also assess the changes in several inflammation and cardiovascular markers,as well as endothelial activation markers,and how these changes relate to therapy-induced changes in immunologic, virologic and metabolic markers.
Key facts
- Study ID
- NCT00575939
- Run by
- University Hospitals Cleveland Medical Center
- People needed
- 120
- Starts
- 2007-11-01
- Expected to finish
- 2014-11-01
- Last updated by the study team
- 2014-12-19
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
Where it is running
- University Hospitals Case Medical Center — Cleveland, Ohio, United States
Full record on ClinicalTrials.gov
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