Idiotype Vaccine After Chemotherapy & Stem Cell Transplantation in Lymphoma With Failed Induction Chemotherapy

Completed · Not applicable

Conditions studied: Lymphoma

In brief

This is a compassionate use protocol for participants who failed induction chemotherapy + Vaccine on previous trials. These participants then went on to high dose BEAM chemotherapy and transplant, then received idiotype vaccine therapy at 3 months post transplant. Vaccine was given monthly x 4 series, with a fifth series given 12 weeks after the fourth. Participants were then followed annually until progression or death with standard staging.

Key facts

Study ID

NCT00574886

Run by

University of Nebraska

People needed

2

Starts

2000-08-03

Expected to finish

2008-04-15

Last updated by the study team

2023-12-08

Who can join

Age: 19 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• histologically confirmed aggressive or indolent, B-cell non-hodgkins lymphoma
• original enrollment in vaccine protocol for newly diagnosed lymphoma and had successful production of idiotype vaccine
• failed to achieve PR or CR with initial induction chemotherapy, received salvage chemotherapy and then stem cell transplant and achieved a CR or good PR following transplantation
• >/= 19 years
• signed informed consent
• non-pregnant, non-lactating

You may not qualify if…

• serious disease or condition that, in the opinion of the investigator, would compromise the subject's ability to participate in the study.

Where it is running

• Unversity of Nebraska Medical Center — Omaha, Nebraska, United States

Full record on ClinicalTrials.gov

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