Metabolic Causes of Thrombosis in Type 2 Diabetes - Question 1
Completed · Not applicable
Conditions studied: Type 2 Diabetes
In brief
The purpose of this study is to learn more about why patients with diabetes have increased heart attacks, strokes and other illnesses due to blood clots causing blockage of a blood vessel. The proposed protocol will study the separate and combined effects of hyperglycemia and hyperinsulinemia on endothelial function and fibrinolytic balance in Type 2 DM. Our hypothesis is that hyperglycemia, rather than hyperinsulinemia, is responsible for the dysregulation of fibrinolytic balance in diabetics.
Key facts
- Study ID
- NCT00574665
- Run by
- Vanderbilt University
- People needed
- 32
- Starts
- 2006-10-01
- Expected to finish
- 2010-12-01
- Last updated by the study team
- 2014-12-11
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- 16 ( 8 female/ 8 male) Type 2 diabetic patients age 18-60 yrs
- 16 ( 8 female/ 8 male) Non-diabetic controls age and weight matched
- Body mass index 25-52 kgm2
- Female volunteers of childbearing potential: negative HCG pregnancy test
- Volunteers over 40 years old: normal baseline ECG
- For those with type 2 diabetes: HBA1C 6.5-10%
You may not qualify if…
- Prior history of poor health: any current or prior disease condition that alters carbohydrate metabolism and prior cardiac events and/or evidence for cardiac disease
- Uncontrolled hypertension
- History of cerebrovascular incidents
- Pregnancy
- Subjects unable to give voluntary informed consent
- Subjects with a recent medical illness
- Subjects with known liver or kidney disease
- Subjects on anticoagulant drugs, anemic, or with known bleeding diseases
- Tobacco Use
Where it is running
- Vanderbilt University — Nashville, Tennessee, United States
Full record on ClinicalTrials.gov
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