Trial of Oral Versus Intravenous Proton Pump Inhibitor on Intragastric pH in Patients With Bleeding Ulcers

Completed · Not applicable

Conditions studied: Peptic Ulcer Hemorrhage

In brief

Patients with bleeding ulcers identified by endoscopy will be randomly assigned to receive an acid-blocking drug (called a proton pump inhibitor \[PPI\]) either by mouth every 3 hours for 24 hours or intravenously (IV) by constant infusion for 24 hours. A pH probe in the stomach will be used to determine intragastric pH (a measure of the acid production in the stomach) at baseline and during the 24 hours of therapy. The purpose of the study is to determine if the continuous intravenous administration of the drug provides better reduction of acid in the stomach than the oral administration.

Key facts

Study ID

NCT00573924

Run by

University of Southern California

People needed

66

Starts

2006-02-01

Expected to finish

2007-12-01

Last updated by the study team

2011-02-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients presenting to hospital with overt upper GI bleeding and found to have an ulcer as the cause on endoscopy

You may not qualify if…

• Previous gastric surgery
• Active bleeding at end of endoscopy (despite hemostatic therapy)
• Recent PPI or H2RA use

Where it is running

• L.A. County + U.S.C. Medical Center — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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