Metabolism of the Insecticide Permethrin

Completed · Not applicable

Conditions studied: Pharmacokinetics, Metabolism

In brief

Military personnel are exposed to the insecticide permethrin when using the DOD Insect Repellent System. A urinary metabolite of permethrin that is in high abundance and is relatively stable may be an ideal biomarker of exposure to this pesticide. Monitoring such a biomarker can prevent over-exposure. The objectives are to identify the most abundant human urinary metabolite following dermal exposure; to utilize this information to develop rapid laboratory-based and field portable methods to monitor the degree of an individual's exposure to permethrin.

Key facts

Study ID

NCT00572884

Run by

University of California, Davis

People needed

6

Starts

2006-02-01

Expected to finish

2007-11-01

Last updated by the study team

2007-12-13

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• self-report healthy adult men and premenopausal women

You may not qualify if…

• unusual alcohol, drug, cigarette use for last 3 years
• unusual exercise program for last 3 years
• under the care of a physician for a disease
• participated in any radioactive drug study
• pregnant
• lactating
• people who rely more on their arm due to illness or injury
• people with neurological or musculoskeletal diseases
• use of permethrin in the last 6 months
• people who apply pesticides as their primary occupation

Where it is running

• CTSC Research Center — Mather, California, United States

Full record on ClinicalTrials.gov

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