Effect of Weight Loss on Myocardial Metabolism and Cardiac Relaxation in Obese Adults

Completed · Not applicable

Conditions studied: Obesity

In brief

Obesity adversely affects myocardial (muscular heart tissue) metabolism, efficiency, and diastolic function. The objective of this study was to determine if weight loss could improve obesity-related myocardial metabolism and efficiency and if these improvements were directly related to improved diastolic function.

Key facts

Study ID

NCT00572624

Run by

Washington University School of Medicine

People needed

51

Starts

2003-06-01

Expected to finish

2014-06-01

Last updated by the study team

2017-05-15

Who can join

Age: 21 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Body mass index (BMI) > 30 kg/m\^2
• Sedentary lifestyle

You may not qualify if…

• Body weight >159 kg
• Insulin-requiring diabetes
• Heart failure
• History of coronary artery disease
• Chest pain
• Untreated sleep apnea
• Being an active smoker
• Pregnant, lactating, or postmenopausal

Where it is running

• Washington University Medical School — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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