Effectiveness of Behavioral Treatments for Obesity and Major Depression in Women
Completed · Not applicable
Conditions studied: Depression, Obesity
In brief
This study will compare the effectiveness of two weight loss programs, one supplemented with health education and the other supplemented with behavioral counseling, in treating women who are depressed and overweight.
Key facts
- Study ID
- NCT00572520
- Run by
- University of Massachusetts, Worcester
- People needed
- 161
- Starts
- 2007-07-01
- Expected to finish
- 2012-04-01
- Last updated by the study team
- 2018-07-05
Who can join
Age: 21 and older, up to 65. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Meets DSM-IV criteria for major depressive disorder
- Score of 12 to 24 on Hamilton Depression Rating Scale (HDRS)
- Body mass index (BMI) of 30 to 40 kg
You may not qualify if…
- Plans to move out of the area during the study
- Current smoker
- Diagnosis of bipolar disorder, a psychotic disorder, bulimia, or post-traumatic stress disorder
- Meets criteria for severe depression (HDRS score greater than 24)
- Diagnosis of type 1 or 2 diabetes
- Plans to have bariatric surgery during the study
- No access to a telephone
- Unable to walk unaided or unable to walk 1/4 mile without stopping
- Does not have written clearance from primary care physician for physical activity
- Presence of a condition that precludes dietary changes (e.g., ulcerative colitis, Crohn's disease, active diverticulitis, renal disease)
- Presence of medical conditions likely to limit lifespan
- Taking prescription weight loss medications
- Initiation of anti-depressant medication within the 3 months prior to study entry
- Taking mood stabilizers, antipsychotic medication, or medications known to affect appetite and/or weight (e.g., corticosteroids)
- Reports active suicidal ideation via SCID interview, a score of 3 on item 24 of the HDRS (active suicidal ideation), or determined to have suicidal potential by clinical staff
- Psychiatric hospitalization in the 12 months prior to study entry
- Currently receiving psychotherapy
Where it is running
- University of Massachusetts Medical School — Worcester, Massachusetts, United States
Full record on ClinicalTrials.gov
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