Clinical Effects of Vitamin D Repletion in Patients With Parkinson's Disease
Stopped early · Phase 4 · Has a placebo group
Conditions studied: Parkinson's Disease
In brief
Retrospective review of records in the Emory Movement Disorders clinic suggests vitamin D deficiency occurs in over 80% of patients with Parkinson's Disease (PD), much more frequently than in internal medicine clinics. Laboratory studies have suggested vitamin D could play a role in the development of PD. In addition, low vitamin D levels have been associated with slower walking speeds, worse memory and thinking, and depression.
Key facts
- Study ID
- NCT00571285
- Run by
- Emory University
- People needed
- 31
- Starts
- 2007-06-01
- Expected to finish
- 2015-09-01
- Last updated by the study team
- 2017-01-24
Who can join
Age: 18 and older, up to 89. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Eligible participants must be able to provide informed consent or have a legal representative (defined by Georgia Law) who can give consent.
- Diagnosis of IPD, based on history of 2/3 cardinal features of PD (tremor, bradykinesia and rigidity) and definite response to dopaminergic therapy.
- Previous serum 25-OH vitamin D concentration measured by treating physician within previous 3 months.
- Eligible participants must be able to complete the study questionnaires and assessments (e.g., participant must be judged able to complete TUG at screening/baseline).
- Participants must be free of active cancer or other serious medical condition which might reasonably preclude their completing the 6-month intervention.
- Participants must be able to complete an 8 meter walk at screening evaluation.
You may not qualify if…
- Patients with PD, H\&Y stage I-IV will be eligible to participate in this study.
- Participants must be ages 18-89 years.
- Patient with a history of hypercalcemia, hypercalciuria, liver failure, end-stage renal disease (National Kidney Foundation Classification Stage 5) or kidney stones within the past 5 years will be excluded.
- Specifically, potential participants with GFR (estimated or measured) <15 ml/min are excluded.
Where it is running
- Emory University — Atlanta, Georgia, United States
Full record on ClinicalTrials.gov
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