Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis (LOGIC)

Paused

Conditions studied: Liver Diseases, Alagille Syndrome, Alpha 1-Antitrypsin Deficiency

In brief

Cholestasis is a condition in which bile is not properly transported from the liver to the small intestine. Cholestasis can be caused by an array of childhood diseases, including the genetic diseases Alagille syndrome (ALGS), alpha-1 antitrypsin (a-1AT) deficiency, bile acid synthesis and metabolism defects, and progressive familial intrahepatic cholestasis (PFIC) or benign recurrent intrahepatic cholestasis(BRIC). This study will investigate the natural history and progression of the four previously mentioned cholestatic liver diseases to provide a better understanding of the causes and effects of the diseases.

Key facts

Study ID

NCT00571272

Run by

Arbor Research Collaborative for Health

People needed

1675

Starts

2007-11-30

Expected to finish

2029-05-31

Last updated by the study team

2026-06-04

Who can join

Age: any, up to 25. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Children and young adults diagnosed with one of the four cholestatic diseases from birth through 25 years old.
• Siblings of participants with alpha-1-antitrypsin deficiency, who are affected with alpha-1-antitrypsin deficiency, but have no evidence of liver disease.
• Both sexes, all races and ethnic groups.
• Participant meets the enrollment criteria for one of the four cholestatic liver diseases.
• Patient and/or parent/legal guardian have the ability to provide written informed consent for enrollment.

You may not qualify if…

• Inability to comply with the longitudinal follow-up described in the protocol.

Where it is running

• Children's Hospital of Los Angeles — Los Angeles, California, United States
• University of California at San Francisco (UCSF) — San Francisco, California, United States
• Children's Hospital Colorado — Aurora, Colorado, United States
• Children's Healthcare of Atlanta - Emory University — Atlanta, Georgia, United States
• Ann & Robert H. Lurie Children's Hospital of Chicago — Chicago, Illinois, United States
• Riley Hospital for Children — Indianapolis, Indiana, United States
• Johns Hopkins University Hospital — Baltimore, Maryland, United States
• St. Louis University - Cardinal Glennon Children's Medical Center — St Louis, Missouri, United States
• Washington University School of Medicine/St. Louis Children's Hospital — St Louis, Missouri, United States
• Mount Sinai School of Medicine — New York, New York, United States
• Cincinnati's Children's Memorial Hospital — Cincinnati, Ohio, United States
• Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
• UPMC Children's Hospital of Pittsburgh — Pittsburgh, Pennsylvania, United States
• Baylor School of Medicine — Houston, Texas, United States
• University of Utah — Salt Lake City, Utah, United States
• Seattle Children's Hospital — Seattle, Washington, United States
• The Hospital for Sick Children — Toronto, Ontario, Canada

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.