Aqueous Outflow Facility Changes With Posture
Completed
Conditions studied: Healthy
In brief
Intraocular pressure (IOP) varies with body position, with a significant increase occurring from the seated to the supine position. Previous research has indicated that the IOP increase cannot be explained by changes in episcleral venous pressure(blood flow leading away from the eye) alone. As well, previous research has indicated that aqueous flow rate is independent of body position. The purpose of this project was to determine if aqueous humor outflow facility varied with changes in posture.
Key facts
- Study ID
- NCT00571012
- Run by
- Mayo Clinic
- People needed
- 20
- Starts
- 2007-10-01
- Expected to finish
- 2007-12-01
- Last updated by the study team
- 2009-11-26
Who can join
Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy, aged 18-45.
- Subjects will be given a complete dilated eye exam and an updated medical history will be performed
You may not qualify if…
- IOP greater than 22mmHg
- Evidence of glaucomatous optic neuropathy
- Poor fixation
- Nystagmus
- Tropias
- Phorias
- Recent infection
- Corneal scarring preventing reliable tonometry
- Evidence of pigment dispersion
- Narrow angles
- History of trauma or surgery
- Systemic use of beta blockers or steroids
- Diabetic eye disease, uveitis, high (>6D) myopia or high(>4D) hyperopia.
- Patients with chronic medical conditions(eg: hypertension) will be allowed to participate as long as their medical condition has been under good control over the preceding 12 months.
- Subjects will also need to have good cervical neck malleability and be able to meet the physical needs of the protocol which call for 4 minutes of neck extension.
Where it is running
- Mayo Clinic — Rochester, Minnesota, United States
Full record on ClinicalTrials.gov
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