Utility of Exercise-induced N-terminal (NT) Pro-brain Natriuretic Peptide Levels in Predicting Prognosis in Asymptomatic Aortic Stenosis

Stopped early · Not applicable

Conditions studied: Aortic Stenosis

In brief

One hundred patients with moderate to severe asymptomatic aortic stenosis (AS) will be asked to exercise on a treadmill. NT-pro-BNP levels will be drawn before and after exercise. Changes in NT-pro-BNP levels will be correlated to outcomes at one year. In the pilot phase an additional 10 control subjects without AS will be enrolled to document the control response of NT-pro-BNP elevations with exercise.

Key facts

Study ID

NCT00567437

Run by

Duke University

People needed

110

Starts

2007-12-01

Expected to finish

2008-12-01

Last updated by the study team

2012-10-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• valvular AS (Doppler velocity ≥ 3.0 m/s)
• no baseline symptoms referable to valvular heart disease
• able to perform ETT

You may not qualify if…

• more than mild aortic regurgitation, mitral regurgitation/ stenosis, or tricuspid regurgitation/stenosis
• previous AVR
• known coronary artery disease
• creatinine clearance 50 mL/min
• LVEF < 50%
• planned valve surgery prior to enrollment
• significant pulmonary disease
• unable to give informed consent
• pregnancy

Where it is running

• Duke University Medical Center — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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