Treating Intention In Aphasia: Neuroplastic Substrates

Completed · Phase 1/Phase 2

Conditions studied: Aphasia, Cerebrovascular Accident

In brief

The purpose of this study is to determine if an "intentional act" improves treatment response for patients with nonfluent aphasia. The treatment involves naming pictures and saying members of categories. The "intentional act" requires initiating picture naming or category member trials with a left-hand movement sequence. Nonfluent aphasia is a disorder of language production in which patients with damage to the brain's language system have trouble initiating and maintaining spoken communication. All patients participating in the study take part in functional MRI scans to determine how treatments affect brain systems.

Key facts

Study ID

NCT00567242

Run by

University of Florida

People needed

14

Starts

2007-03-01

Expected to finish

2009-09-01

Last updated by the study team

2012-05-03

Who can join

Age: 21 and older, up to 95. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Nonfluent aphasia caused by stroke
• Moderate to severe word-finding problems
• 6 or more months post stroke
• Right handed prior to stroke
• All strokes in left hemisphere
• Native English speaker
• Capable of following verbal directions

You may not qualify if…

• Severe impairment of word comprehension
• Brain injury or disease in addition to stroke
• Drug or alcohol abuse within past 6 months
• Schizophrenia or other psychiatric disorder necessitating hospitalization
• History of learning disability
• Claustrophobia
• Cardiac pace-maker
• Ferrous metal implants not attached to bone, metal fragments in body
• Profound hearing loss

Where it is running

• University of Florida — Gainesville, Florida, United States
• University of Florida/Shands Hospital — Jacksonville, Florida, United States
• Brooks Center for Rehabilitation Studies — Jacksonville, Florida, United States

Full record on ClinicalTrials.gov

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