Memantine in Preventing Side Effects in Patients Undergoing Whole-Brain Radiation Therapy for Brain Metastases From Solid Tumors

Completed · Phase 3 · Has a placebo group

Conditions studied: Cognitive/Functional Effects, Metastatic Cancer, Neurotoxicity, Unspecified Adult Solid Tumor, Protocol Specific

In brief

RATIONALE: Memantine may be able to decrease side effects caused by whole-brain radiation therapy. It is not yet known if memantine is effective in preventing side effects caused by whole-brain radiation therapy. PURPOSE: This randomized phase III trial is studying memantine to see how well it works compared to a placebo in preventing side effects caused by whole-brain radiation therapy in patients with brain metastases from solid tumors.

Key facts

Study ID

NCT00566852

Run by

Radiation Therapy Oncology Group

People needed

554

Starts

2008-03-01

Expected to finish

2016-12-01

Last updated by the study team

2017-08-21

Who can join

Age: 18 and older, up to 120. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Providence Cancer Center at Providence Hospital — Mobile, Alabama, United States
• Arizona Oncology Services Foundation — Phoenix, Arizona, United States
• Mayo Clinic Scottsdale — Scottsdale, Arizona, United States
• Arizona Oncology - Tucson — Tucson, Arizona, United States
• Arizona Cancer Center at University of Arizona Health Sciences Center — Tucson, Arizona, United States
• Auburn Radiation Oncology — Auburn, California, United States
• Providence Saint Joseph Medical Center - Burbank — Burbank, California, United States
• Radiation Oncology Centers - Cameron Park — Cameron Park, California, United States
• Mercy Cancer Center at Mercy San Juan Medical Center — Carmichael, California, United States
• Enloe Cancer Center at Enloe Medical Center — Chico, California, United States
• Cancer Care Center at John Muir Health - Concord Campus — Concord, California, United States
• City of Hope Comprehensive Cancer Center — Duarte, California, United States
• Glendale Adventist Medical Center — Glendale, California, United States
• Rebecca and John Moores UCSD Cancer Center — La Jolla, California, United States
• Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center — Los Angeles, California, United States
• USC/Norris Comprehensive Cancer Center and Hospital — Los Angeles, California, United States
• St. Joseph Hospital Regional Cancer Center - Orange — Orange, California, United States
• Radiation Oncology Center - Roseville — Roseville, California, United States
• Radiological Associates of Sacramento Medical Group, Incorporated — Sacramento, California, United States
• University of California Davis Cancer Center — Sacramento, California, United States
• Mercy General Hospital — Sacramento, California, United States
• Stanford Cancer Center — Stanford, California, United States
• Emanuel Regional Cancer Services at Emanuel Medical Center — Turlock, California, United States
• Solano Radiation Oncology Center — Vacaville, California, United States
• MBCCOP - Gulf Coast — Mobile, Alabama, United States

Full record on ClinicalTrials.gov

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