Evaluating the Roles of Estrogen and Progesterone in Heart Metabolism

Stopped early · Not applicable · Has a placebo group

Conditions studied: Postmenopausal Syndrome

In brief

Estrogen and progesterone are two main female sex hormones. When a woman goes through menopause, the body's production of estrogen and progesterone significantly decreases. Recent studies have shown that the breakdown of fatty acids in cardiac muscle is important in maintaining a healthy heart, and that estrogen may enhance this process. Also, cardiovascular disease (CVD) occurs more frequently in postmenopausal women than in premenopausal women. This study will determine in postmenopausal women whether estrogen increases the heart's ability to use fats as energy and whether progesterone decreases this effect.

Key facts

Study ID

NCT00565916

Run by

Washington University School of Medicine

People needed

22

Starts

2004-08-01

Expected to finish

2008-01-01

Last updated by the study team

2018-10-16

Who can join

Age: 55 and older, up to 75. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Healthy postmenopausal woman
• Body mass index less than 30
• Practices normal eating habits
• Stops hormone replacement therapy at least 6 months prior to study entry

You may not qualify if…

• Currently taking hormone replacement therapy
• History of cardiovascular disease
• Family history of coronary artery disease
• Recent history of smoking, high blood pressure, or hyperlipidemia

Where it is running

• Washington University School of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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