Sensorimotor Gating in Schizophrenia
Completed · Not applicable
Conditions studied: Schizophrenia
In brief
This study is looking at problems people sometimes have taking in information from their senses. Specifically, we are comparing the way in which people diagnosed with schizophrenia process sound information, compared with people who have never been diagnosed with a psychiatric disorder. When people hear a loud sound they sometimes feel startled, and when they feel startled they usually blink their eyes. However, if they hear a softer sound shortly before the loud one they may not blink their eyes - in other words, the eye-blink response is smaller. When this happens it's called prepulse inhibition of startle. In this study, we want to measure the startle response and prepulse inhibition of startle in individuals diagnosed with schizophrenia versus individuals not diagnosed with schizophrenia. We also want to find out whether people show the same amount of prepulse inhibition of startle as other members of their family.
Key facts
- Study ID
- NCT00561561
- Run by
- Emory University
- People needed
- 531
- Starts
- 2001-06-01
- Expected to finish
- 2011-08-26
- Last updated by the study team
- 2019-08-07
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Diagnosis of a Schizophrenia Spectrum disorder OR no history of Psychiatric Illness
You may not qualify if…
- History of head injury with loss of consciousness of more than 5 minutes
- History of neurological disease (ex. meningitis, encephalitis)
- Drug or alcohol abuse within the last 3 months
- Hearing loss
- Non-correctable vision problems
- Current cancer treatment (radiation or chemotherapy currently ongoing)
- History of Post Traumatic Stress Disorder
- Diagnosis of HIV or AIDS
- Uncontrolled diabetes
- History of seizures
Where it is running
- Atlanta VA Medical Center — Decatur, Georgia, United States
Full record on ClinicalTrials.gov
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