High Dose CVVHDF Compared to Standard Dose CVVHDF
Completed · Phase 3
Conditions studied: Acute Renal Failure
In brief
In the last three decades, the mortality associated with acute renal failure (ARF) in the ICU has remained unchanged at greater than 50%, despite improvements in dialysis technology. The primary objective is to determine whether Continuous Veno-Venous Hemodiafiltration (CVVHDF) using an ultrafiltration rate of 35 ml/hr/kg (high dose) leads to a greater reduction in all-cause ICU mortality compared to standard CVVHDF using an ultrafiltration rate of 20 ml/hr/kg.
Key facts
- Study ID
- NCT00561431
- Run by
- University of Alabama at Birmingham
- People needed
- 200
- Starts
- 2003-07-01
- Expected to finish
- 2007-11-01
- Last updated by the study team
- 2015-04-14
Who can join
Age: 19 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male or female > or equal to 19 yrs of age
- ARF defined by at least one of the following:
- Volume overload from inadequate urine output despite diuretic agents.
- Oliguria (urine output < 200 ml/12hrs) despite fluid resuscitation and diuretic administration.
- Anuria (urine output < 50 ml/12 hrs).
- Acute azotemia (BUN > or equal to 80 mg/dl).
- Acute hyperkalemia not responsive to medication (K+ > or equal to 6.5mmol/L)
- An increase in serum creatinine of > 2.5 mg/dl from normal values or a sustained rise in serum creatinine of > or equal to 1 mg/dl over baseline.
You may not qualify if…
- Patients with end stage renal disease
- Patients who have had more than one previous dialysis session for acute or chronic renal failure during the current hospitalization
- Patient weight greater than 125 kg
- Patient weight less than 50 kg
- Pregnancy
- Prisoner
- Non-candidacy for continuous renal replacement therapy (CRRT)
- Patient/surrogate refusal
Where it is running
- The University of Alabama at Birmingham — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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