Identifying Shared Genetic Susceptibility Regions in Chronic Beryllium Disease and Sarcoidosis

Completed

Conditions studied: Sarcoidosis, Berylliosis

In brief

Granulomatous lung diseases are diseases in which inflamed clusters of white cells, known as granulomas, form in lung tissue. Chronic beryllium disease (CBD) and sarcoidosis are two granulomatous diseases that share similar clinical symptoms, physiological changes in the lungs, and immune responses to the disease. Genetic variations may make some people more susceptible to developing CBD or sarcoidosis. This study will identify common genetic regions associated with increased risk of developing the granulomatous diseases CBD and sarcoidosis.

Key facts

Study ID

NCT00560989

Run by

National Jewish Health

People needed

400

Starts

2007-03-01

Expected to finish

2007-03-01

Last updated by the study team

2014-09-26

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Has previously participated in beryllium studies conducted by Dr. Lisa Maier
• Agrees to allow the use of personal medical records and genetic material for future research by study officials

You may not qualify if…

• Will not consent for use of DNA for research purposes or for storage
• Any beryllium or sarcoidosis DNA specimens without an optical density of 260/280 nm, ratio between 1.8 and 2.0, or with an insufficient quantity of DNA for analysis purposes

Where it is running

• National Jewish Medical and Research Center — Denver, Colorado, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.