Flavonoid Effect on Activation and Stimulation of Thrombocytes, hsCRP and Lipid Profile

Completed · Not applicable

Conditions studied: Healthy

In brief

The purpose of this study is to compare the effect of dark chocolate with green tea in healthy subjects on clot formation (platelet activity) cholesterol profile and markers of inflammation in two groups. The first group will be on a regimen of dark chocolate, and the second group will be on a regimen of green tea. Clinical outcomes will be determined after seven days of each treatment and both groups will undergo both treatments subsequently and serve as their own control. The hypothesis is that both green tea and dark chocolate will reduce platelet activity and reduce LDL, hsCRP and increase HDL.

Key facts

Study ID: NCT00559663
Run by: LifeBridge Health
People needed: 35
Starts: 2006-09-01
Expected to finish: 2007-04-01
Last updated by the study team: 2007-11-20

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

non-smokers between the ages of 18-60
BMI of 19 to 30

You may not qualify if…

prior usage of Vitamin C > 1000 mg, Vitamin E > 400IU, Beta Carotene > 1000IU, Vitamin A > 5000IU, Selenium > 200mcg, Folic Acid > 1mg, Aspirin or NSAIDs four weeks prior to study initiation
regular ingestion of Flavonoid rich food (EG green tea, dark chocolate, grapes, red wine and others) prior and during the study except what was provided by the study protocol
Alcohol or Caffeine consumption 24 prior to blood draws
Nursing or pregnant women
blood donation up to eight weeks prior to study initiation
subjects with coagulation disorders
known cardiovascular disease (prior myocardial infarction)
drug abuse
Diabetes

Where it is running

Center for Thrombosis Research, Sinai Hospital — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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