Clazosentan in Reducing Vasospasm-related Morbidity and All-cause Mortality in Adult Patients With Aneurysmal Subarachnoid Hemorrhage Treated by Surgical Clipping

Completed · Phase 3 · Has a placebo group

Conditions studied: Aneurysmal Subarachnoid Hemorrhage

In brief

The aim of this study is to demonstrate that clazosentan, administered as a continuous intravenous infusion at 5 mg/h until Day 14 post aneurysmal subarachnoid hemorrhage (aSAH), reduces the incidence of cerebral vasospasm -related morbidity and all-cause mortality within 6 weeks post-aSAH treated by surgical clipping. The primary endpoint of the study is the occurrence of cerebral vasospasm-related morbidity, and mortality of all-causes within 6 weeks post-aSAH, defined by at least one of the following: 1. Death (all causes). 2. New cerebral infarct(s) due to cerebral vasospasm as either the primary or relevant contributing cause, or not adjudicated to be entirely due to causes other than vasospasm. 3. Delayed ischemic neurological deficit (DIND) due to cerebral vasospasm as either the primary or relevant contributing cause, or not adjudicated to be entirely due to causes other than vasospasm. 4. Neurological signs or symptoms (depending on state of consciousness), in the presence of confirmed cerebral vasospasm on angiography (DSA or CTA), leading to the administration of a valid rescue therapy. An independent Critical Events Committee (CEC) will adjudicate whether or not patients meet the primary endpoint and its individual morbidity components.

Key facts

Study ID

NCT00558311

Run by

Idorsia Pharmaceuticals Ltd.

People needed

1157

Starts

2007-12-14

Expected to finish

2010-07-13

Last updated by the study team

2020-02-17

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Males and females aged 18 to 75 years (inclusive).
• Patients with a ruptured saccular aneurysm, confirmed by angiography (digital subtraction angiography [DSA] or computed tomography angiography [CTA]), and which has been successfully secured by surgical clipping. The time of aneurysm rupture must be known or possible to estimate with a reasonable degree of certainty.
• World Federation of Neurological Surgeons (WFNS) grade I-IV measured prior to the clipping procedure, and which does not worsen to grade V post-procedure (based on regular Glasgow Coma Scale [GCS])*
• Patients with any diffuse clot (long axis > or = 20 mm, or any clot present across both hemispheres) on baseline CT scan.
• Women of childbearing potential must have a negative serum pregnancy test and must use a reliable method of contraception during the 12 weeks following study drug discontinuation.
• Written informed consent to participate in the study must be obtained from the patient or a legal representative prior to initiation of any study-mandated procedure and randomization.
• Patients must be evaluable for WFNS grade prior to the clipping procedure. Patients who cannot be assessed for WFNS post-procedure due to a requirement for uninterrupted sedation (e.g., for high or unstable intracranial pressure [ICP]) may be included in the study provided that a CT scan is performed at 12 hours post-procedure, but prior to randomization, ruling out any large procedure-related infarct.

You may not qualify if…

• Patients with subarachnoid hemorrhage (SAH) due to causes other than a saccular aneurysm (e.g., trauma or rupture of fusiform or mycotic aneurysms).
• Patients with intraventricular or intracerebral blood, in the absence of subarachnoid blood, or with only a local clot.
• Presence of cerebral vasospasm seen on angiography prior to the clipping procedure.
• Patients who experienced a major complication during the clipping procedure, such as massive bleeding, major arterial occlusion, a large territorial cerebral infarct defined as involving > 1/3 of a vascular territory, or a new major neurological deficit post-procedure (e.g., hemiplegia or aphasia lasting > or = 12 hours post-aneurysm clipping).*
• Patients for whom study drug cannot be started within 56 hours after the aneurysm rupture.
• Patients who have had their aneurysm secured by coiling only.
• Patients for whom it is known, at the time of screening, that certain follow-up, protocol-mandated imaging assessments will not be feasible.
• Patients with hypotension (systolic blood pressure (SBP)< or = 90 mmHg) that is refractory to treatment.
• Patients with aspiration pneumonia.
• Patients with pulmonary edema or severe cardiac failure requiring inotropic support.
• Any severe or unstable concomitant condition or disease (e.g., known significant neurological deficit, cancer, hematological, or coronary disease), or chronic condition (e.g., psychiatric disorder), which, in the opinion of the investigator, would affect the assessment of the safety or efficacy of the study drug.
• Significant kidney and/or liver disease, as defined by plasma creatinine > or = 2.5 mg/dL (221 micromol/l) and/or total bilirubin > 3 mg/dL (51.3 micromol/l) measured at the local site laboratory.
• Patients receiving i.v. nimodipine, i.v. nicardipine, or fasudil hydrochloride, must have these drugs discontinued at least 4 hours prior to initiation of the study treatment.
• Patients receiving statins for less than 2 weeks prior to admission must have them discontinued prior to study drug initiation.
• Patients receiving cyclosporin A or other calcineurin inhibitors (e.g., tacrolimus), or patients for whom it is known at the time of randomization that these medications will be started during the study drug infusion period.
• Patients who have received an investigational product within 28 days prior to randomization or those who have already participated in the current study.
• Patients unlikely to comply with the protocol (e.g., unable to return for follow-up visits).
• Known hypersensitivity to other endothelin receptor antagonists.
• Patients with current alcohol or drug abuse or dependence.
• Further detail on exclusion criterion number 4:
• "Large territorial infarct" refers to those infarcts detected during the clipping procedure or immediately post-procedure (i.e., CT performed for suspicion of cerebral infarct or other complication). This does not imply having to wait 24-48 hours post-procedure to perform the protocol-mandated CT scan in order to randomize a patient.
• Evaluation for a new major neurological deficit post-procedure implies the reversal of sedation (or waiting for the patient to recover from sedation) and the performance of a GCS examination (verbal scores in intubated patients may be extrapolated from the eye-opening and motor scores using the values provided in the table included in Section 3.9.1.2.1 of the protocol). In the event of a new major neurological deficit that does not improve within 12 hours after the clipping procedure, the patient cannot be included in the study.

Where it is running

• Colorado Neurological Institute — Englewood, Colorado, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States
• Columbia University Medical Center — New York, New York, United States
• State University of New York at Stony Brook-Health Sciences Center — Stony Brook, New York, United States
• University of Cincinnati-Department of Neurosurgery — Cincinnati, Ohio, United States
• University Hospitals Case Medical Center-Department of Neurosurgery — Cleveland, Ohio, United States
• Oregon Health & Science University-Oregon Stroke Center — Portland, Oregon, United States
• Thomas Jefferson University School of Medicine-Jefferson Hospital for Neuroscience — Philadelphia, Pennsylvania, United States
• University of Virginia Health System-Department of Neurosurgery — Charlottesville, Virginia, United States
• Virginia Commonwealth University-Department of Neurosurgery — Richmond, Virginia, United States
• Royal Brisbane Hospital — Herston, Australia
• The Alfred Hospital — Melbourne, Australia
• Landeskrankenhaus — Feldkirch, Austria
• Landeskrankenhaus und Medizinische Universitat Graz — Graz, Austria
• Medizinsche Universitat — Innsbruck, Austria
• University Fur Neurochirurgie, SALK, Christian Doppler Hospital — Salzburg, Austria
• AKH University of Vienna, Medical University — Vienna, Austria
• Sozialmedizinisches Zentrum Ost (ZMZ-Ost) Donauspital Vienna — Vienna, Austria
• Cliniques Universitaires Saint-Luc, Universite Catholique de — Brussels, Belgium
• University of Alberta Hospital — Edmonton, Alberta, Canada
• Vancouver Hospital — Vancouver, British Columbia, Canada
• St Michael's Hospital, University — Toronto, Ontario, Canada
• CHUM Notre Dame — Montreal, Quebec, Canada
• University of Calgary Foothills Medical Center — Calgary, Canada
• Barrow Neurosurgical Associates — Phoenix, Arizona, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.