Minocycline to Prevent Acute Kidney Injury After Cardiac Surgery

Completed · Not applicable · Has a placebo group

Conditions studied: Kidney Failure, Acute, Acute Kidney Insufficiency

In brief

This study proposes to investigate whether treatment with minocycline pre-operatively in patients with mild to moderate chronic kidney disease undergoing cardiac surgery will reduce the occurence of kidney injury.

Key facts

Study ID

NCT00556491

Run by

Tarek M. El-Achkar

People needed

40

Starts

2007-12-01

Expected to finish

2013-12-01

Last updated by the study team

2017-12-22

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age over 18 years
• planned CABG or valvular surgery with cardiopulmonary bypass
• Serum creatinine available (within 30 days)
• Estimated GFR 15-90ml/min using the abbreviated MDRD formula (CKD stages 2-4)

You may not qualify if…

• Emergent or urgent surgery (to be performed within the next 36 hours)
• End stage renal disease, or GFR < 15ml/min (CKD stage 5)
• Estimated GFR>90ml/min (CKD stage 1 or no CKD)
• Ongoing infection by positive blood, urine or sputum cultures or pneumonia on CXR
• Allergy to minocycline or tetracyclines
• inability to take oral medications
• use of preoperative vasopressor agents at therapeutic doses
• Pregnant or lactating females
• Advanced liver disease by history or exam(cirrhosis, ascitis, jaundice)
• Rising creatinine meeting the definition of acute kidney injury prior to surgery
• Neurologic signs or symptoms or history of increased intracranial pressure
• current participation in another research study involving an investigational drug or device

Where it is running

• Saint Louis University — St Louis, Missouri, United States
• Montefiore Medical Center — The Bronx, New York, United States

Full record on ClinicalTrials.gov

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