Brain, Gut and Kidney Blood Flow During Medical Closure of PDA

Withdrawn before enrolling

Conditions studied: Patent Ductus Arteriosus

In brief

The purpose of this study is to determine how the medications which are used to close the patent ductus arteriosus (PDA) in preterm infants affect brain, kidney and gut blood flow when compared to infants that are not treated with these medications. The medications being used for PDA closure are indomethacin and neoprofen.

Key facts

Study ID

NCT00554307

Run by

University of Louisville

People needed

0

Starts

2007-11-01

Expected to finish

2009-12-01

Last updated by the study team

2015-01-26

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Less than or equal to 32 weeks gestation;
• Less than or equal to 1250 g;
• Mechanical ventilation;
• Echocardiographic findings of PDA with left to right shunting;
• Medical judgement of neonatologist for medical treatment;

You may not qualify if…

• Urine output less than 1 ml/k/hr over previous 12 hours;
• Serum creatinine greater than 1.5 mg/dL;
• Platelet count less than 100,000 per cubic mm;
• Significant skin breakdown at sensor areas;
• Significant congenital anomalies
• Intraventricular hemorrhage greater than or equal to grade III

Where it is running

• Kosair Children's Hospital — Lousiville, Kentucky, United States

Full record on ClinicalTrials.gov

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