Efficacy of Coreg CR and Lisinopril on Markers for Cardiovascular Functional and Structural Disease
Completed · Phase 1/Phase 2 · Has a placebo group
Conditions studied: Pre-hypertension
In brief
This study will examine the individual and combined effects of Coreg CR and lisinopril, on cardiovascular health as measured by Rasmussen Disease Score (RDS) in a blinded, placebo controlled comparison over a 9-month study period. Patients to be randomized will have pre-hypertensive blood pressures that do not require anti-hypertensive therapy and at least one additional cardiovascular risk factor.
Key facts
- Study ID
- NCT00553969
- Run by
- University of Minnesota
- People needed
- 101
- Starts
- 2007-11-01
- Expected to finish
- 2010-12-01
- Last updated by the study team
- 2018-04-24
Who can join
Age: 19 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Males and females > 18 years old with pre-hypertensive or borderline blood pressures (systolic blood pressure ≥ 130 mmHg or diastolic blood pressure ≥ 85 mmHg) deemed not to need antihypertensive therapy. Subjects must also have one additional risk factor for cardiovascular disease, including:
- LDL > 130 and < 160 mg/dL
- HDL < 40 mg/dL
- Fasting blood sugar >100 and < 126 mg/dL
- Body mass index ≥ 30
- Smoker
- Family history of premature heart disease or hypertension
You may not qualify if…
- Patients with a history of cardiac, cerebral or other vascular events within the previous 6 months will be excluded. Other exclusions include background therapy with a beta blocker or ACE inhibitor therapy, known or suspected intolerance to beta blockers or ACE inhibitors, angiotensin receptor blocker therapy, or diabetes. Pregnant or lactating women, and women of child-bearing age who are not using an acceptable form of contraception are also excluded from this study.
Where it is running
- University of Minnesota, Variety Club Research Center 102 — Minneapolis, Minnesota, United States
Full record on ClinicalTrials.gov
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