Pharmacokinetics of Ketamine in Infants and Children

Completed · Not applicable

Conditions studied: The Pk of IV Ketamine in Children With Heart Disease

In brief

Dosing of medications is based on the plasma level achieved with a given dose and how long the medicine remains in the body. This study is called pharmacokinetics-that is, what the body does to the medication. Ketamine is an intravenous medication used for anesthesia and sedation in children. However the pharmacokinetics of Ketamine has not been systematically studied. We propose to study the pharmacokinetics of ketamine in different age groups of children ranging from infants to teenagers.

Key facts

Study ID

NCT00553839

Run by

Stanford University

People needed

21

Starts

2007-07-01

Expected to finish

2009-01-01

Last updated by the study team

2016-02-08

Who can join

Age: any, up to 17. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Term infants (38 weeks gestation)and infants and children up to age 18 years.
• Patients who require procedures that necessitate at least 8 hours in the hospital and those being admitted after procedure will be eligible to participate.
• Patients who will receive ketamine as part of their standard anesthesia regimen.

You may not qualify if…

• Preterm neonates
• Liver Disease
• Kidney disease
• Heart failure
• Sepsis
• Patients receiving anticonvulsants or barbiturates

Where it is running

• The Children's Hospital — Denver, Colorado, United States
• Lucile Packard Children's Hospital — Palo Alto, California, United States

Full record on ClinicalTrials.gov

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