Carboplatin and Paclitaxel Albumin-Stabilized Nanoparticle Formulation Followed by Radiation Therapy and Erlotinib in Treating Patients With Stage III Non-Small Cell Lung Cancer That Cannot Be Removed By Surgery

Completed · Phase 2

Conditions studied: Lung Cancer

In brief

RATIONALE: Drugs used in chemotherapy, such as carboplatin and paclitaxel albumin-stabilized nanoparticle formulation, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Erlotinib may make tumor cells more sensitive to radiation therapy. Giving carboplatin and paclitaxel albumin-stabilized nanoparticle formulation together with radiation therapy and erlotinib may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving carboplatin and paclitaxel albumin-stabilized nanoparticle formulation together with radiation therapy and erlotinib works in treating patients with stage III non-small cell lung cancer that cannot be removed by surgery.

Key facts

Study ID

NCT00553462

Run by

Alliance for Clinical Trials in Oncology

People needed

78

Starts

2008-03-01

Expected to finish

2017-06-15

Last updated by the study team

2018-01-31

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Valley Medical Oncology Consultants - Castro Valley — Castro Valley, California, United States
• Valley Medical Oncology — Fremont, California, United States
• Contra Costa Regional Medical Center — Martinez, California, United States
• Camino Medical Group - Treatment Center — Mountain View, California, United States
• El Camino Hospital Cancer Center — Mountain View, California, United States
• Highland General Hospital — Oakland, California, United States
• Alta Bates Summit Medical Center - Summit Campus — Oakland, California, United States
• Bay Area Breast Surgeons, Incorporated — Oakland, California, United States
• CCOP - Bay Area Tumor Institute — Oakland, California, United States
• Larry G Strieff MD Medical Corporation — Oakland, California, United States
• Tom K Lee, Incorporated — Oakland, California, United States
• Palo Alto Medical Foundation — Palo Alto, California, United States
• Doctors Medical Center - San Pablo Campus — San Pablo, California, United States
• Poudre Valley Radiation Oncology — Fort Collins, Colorado, United States
• Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center — Hartford, Connecticut, United States
• Tunnell Cancer Center at Beebe Medical Center — Lewes, Delaware, United States
• CCOP - Christiana Care Health Services — Newark, Delaware, United States
• Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital — Fort Lauderdale, Florida, United States
• University of Florida Shands Cancer Center — Gainesville, Florida, United States
• Ella Milbank Foshay Cancer Center at Jupiter Medical Center — Jupiter, Florida, United States
• CCOP - Mount Sinai Medical Center — Miami Beach, Florida, United States
• University of Chicago Cancer Research Center — Chicago, Illinois, United States
• Hematology Oncology Associates of the Quad Cities — Bettendorf, Iowa, United States
• Menorah Medical Center — Overland Park, Kansas, United States
• East Bay Radiation Oncology Center — Castro Valley, California, United States

Full record on ClinicalTrials.gov

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