Letrozole in Preventing Cancer in Postmenopausal Women Who Have Received 4-6 Years of Hormone Therapy for Hormone Receptor-Positive, Lymph Node-Positive, Early-Stage Breast Cancer

Completed · Phase 3

Conditions studied: Breast Cancer

In brief

RATIONALE: Estrogen can cause the growth of breast cancer cells. Letrozole may fight breast cancer by lowering the amount of estrogen the body makes. It is not yet known which regimen of letrozole is more effective in postmenopausal women who have received hormone therapy for early-stage breast cancer. PURPOSE: This randomized phase III trial is comparing two different regimens of letrozole in preventing cancer in postmenopausal women who have received 4-6 years of hormone therapy for hormone receptor-positive, lymph node-positive, early-stage breast cancer.

Key facts

Study ID

NCT00553410

Run by

ETOP IBCSG Partners Foundation

People needed

4884

Starts

2007-08-01

Expected to finish

2019-05-15

Last updated by the study team

2020-03-11

Who can join

Age: 18 and older, up to 120. Sex: female. Healthy volunteers: not accepted.

Where it is running

• Faulkner Hospital — Boston, Massachusetts, United States
• Armidale Hospital — Armidale, New South Wales, Australia
• Bankstown - Lidcombe Hospital — Bankstown, New South Wales, Australia
• Southern Highlands Cancer Center — Bowral, New South Wales, Australia
• Concord Repatriation General Hospital — Concord, New South Wales, Australia
• Breast Center — Gateshead, New South Wales, Australia
• Port Mcquarie Base Hospital — Port Macquarie, New South Wales, Australia
• Prince of Wales Private Hospital — Randwick, New South Wales, Australia
• Tamworth Base Hospital — Tamworth, New South Wales, Australia
• Tweed Heads Hospital — Tweed Heads, New South Wales, Australia
• Calvary Mater Newcastle — Waratah, New South Wales, Australia
• North West Regional Hospital — Burnie, Tasmania, Australia
• Royal Hobart Hospital — Hobart, Tasmania, Australia
• Box Hill Hospital — Box Hill, Victoria, Australia
• Peter MacCallum Cancer Centre — East Melbourne, Victoria, Australia
• Austin Health — Heidelberg, Victoria, Australia
• Maroondah Hospital — Melbourne, Victoria, Australia
• Royal Perth Hospital — Perth, Western Australia, Australia
• Landeskrankenhaus Feldkirch — Feldkirch, Austria
• Medizinische Universitaet Graz — Graz, Austria
• Innsbruck Universitaetsklinik — Innsbruck, Austria
• Krankenhaus BHS Linz — Linz, Austria
• Allgemeines Krankenhaus Linz — Linz, Austria
• St. Johanns-Spital — Salzburg, Austria
• Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.