Donor Stem Cell Transplant in Treating Young Patients With Acute Myeloid Leukemia With Monosomy 7, -5/5q-, High FLT3-ITD AR, or Refractory or Relapsed Acute Myelogenous Leukemia
Completed · Phase 2
Conditions studied: Leukemia
In brief
RATIONALE: Giving chemotherapy before a donor stem cell transplant using stem cells that closely match the patient's stem cells, helps stop the growth of cancer cells. It also stops the patient's immune system from rejecting the donor's stem cells. The donated stem cells may replace the patient's immune cells and help destroy any remaining cancer cells (graft-versus-tumor effect). Sometimes the transplanted cells from a donor can also make an immune response against the body's normal cells. Giving antithymocyte globulin before transplant and cyclosporine, tacrolimus, and methotrexate before and after transplant may stop this from happening. PURPOSE: Natural Killer (NK) cells from the donor's bone marrow may be important in fighting leukemia. Bone marrow donors can be selected based on the type of NK cells they have, specifically the killer immunoglobulin receptor (KIR) type. This study provides information on KIR type from potential donors, which can be used in selecting the bone marrow donor. This phase II trial of unrelated donor stem cell transplant in patients with high risk AML (monosomy 7, -5/5q-, high FLT3-ITD AR, or refractory or relapsed AML) in which KIR typing of the patients and potential donors will be available to the treating transplant physician at the time of donor selection.
Key facts
- Study ID
- NCT00553202
- Run by
- Children's Oncology Group
- People needed
- 158
- Starts
- 2008-01-01
- Expected to finish
- 2020-03-31
- Last updated by the study team
- 2020-04-16
Who can join
Age: any, up to 30. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Phoenix Children's Hospital — Phoenix, Arizona, United States
- Jonathan Jaques Children's Cancer Center at Miller Children's Hospital — Long Beach, California, United States
- Children's Hospital Central California — Madera, California, United States
- Rady Children's Hospital - San Diego — San Diego, California, United States
- Alfred I. duPont Hospital for Children — Wilmington, Delaware, United States
- Children's National Medical Center — Washington D.C., District of Columbia, United States
- Lee Cancer Care of Lee Memorial Health System — Fort Myers, Florida, United States
- Nemours Children's Clinic — Jacksonville, Florida, United States
- Nemours Children's Clinic - Orlando — Orlando, Florida, United States
- Nemours Children's Clinic - Pensacola — Pensacola, Florida, United States
- All Children's Hospital — St. Petersburg, Florida, United States
- AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Egleston Campus — Atlanta, Georgia, United States
- Riley's Children Cancer Center at Riley Hospital for Children — Indianapolis, Indiana, United States
- Holden Comprehensive Cancer Center at University of Iowa — Iowa City, Iowa, United States
- Lucille P. Markey Cancer Center at University of Kentucky — Lexington, Kentucky, United States
- Kosair Children's Hospital — Louisville, Kentucky, United States
- Alvin and Lois Lapidus Cancer Institute at Sinai Hospital — Baltimore, Maryland, United States
- Barbara Ann Karmanos Cancer Institute — Detroit, Michigan, United States
- Mayo Clinic Cancer Center — Rochester, Minnesota, United States
- University of Mississippi Cancer Clinic — Jackson, Mississippi, United States
- Children's Mercy Hospital — Kansas City, Missouri, United States
- Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis — St Louis, Missouri, United States
- UNMC Eppley Cancer Center at the University of Nebraska Medical Center — Omaha, Nebraska, United States
- CCOP - Nevada Cancer Research Foundation — Las Vegas, Nevada, United States
- UAB Comprehensive Cancer Center — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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