Cidofovir in Treating HIV-Infected Patients With High-Grade Squamous Intraepithelial Lesions of the Skin Near the Anus

Completed · Phase 2

Conditions studied: Anal Cancer, Precancerous Condition

In brief

RATIONALE: High-grade squamous intraepithelial lesions of the skin near the anus are caused by the human papillomavirus (HPV). Antiviral drugs,, such as cidofovir, act against viruses and may stop these lesions from becoming cancer. PURPOSE: This phase II trial is studying the side effects and how well topical cidofovir works in treating HIV-infected patients with high-grade squamous intraepithelial lesions of the skin near the anus.

Key facts

Study ID

NCT00550589

Run by

AIDS Malignancy Consortium

People needed

33

Starts

2007-09-01

Expected to finish

2010-02-01

Last updated by the study team

2015-12-21

Who can join

Age: 18 and older, up to 120. Sex: any. Healthy volunteers: not accepted.

Where it is running

• UCLA Clinical AIDS Research and Education (CARE) Center — Los Angeles, California, United States
• UCSF Helen Diller Family Comprehensive Cancer Center — San Francisco, California, United States
• Boston University Cancer Research Center — Boston, Massachusetts, United States
• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
• Laser Surgery Care — New York, New York, United States
• New York Weill Cornell Cancer Center at Cornell University — New York, New York, United States
• Montefiore Medical Center — The Bronx, New York, United States
• Benaroya Research Institute at Virginia Mason Medical Center — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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